Mitotic indices of human bone marrow cells. I. Number and cytologic distribution of mitoses.

By SVEN-AGE KILLMANN, EUGENE P. CRONKITE, T. M. FLIEDNER AND VIc’roR P. BOND T HE OBJECTIVES of the present papers are threefold: In part I, data on the mitotic indices of specific cell types ( specific mitotic index ) in normal human bone marrow will be presented. In part II, restrictions in the use of mitotic index for computation of cytologic time parameters which have not been appreciated in previous work in this field will be pointed out. Failure to observe these restrictions may lead to erroneous estimates of cytologic time parameters. in part III, the observed specific mitotic indices will be applied in computations of time parameters of hemopoietic cell proliferation in accordance with these restrictions.